Research Summary

I am Professor of Medicine and Dermatology emeritus on call back at UCSF and staff Endocrinologist at SFVAMC. I continue both my clinical activities and direct a well funded laboratory investigating hormonal regulation of fracture healing and vitamin D and calcium regulation of both skin cancer and wound response.

Research Funding

  • October 1, 2022 - September 30, 2026 - BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to bone (FRACTURECURB): Role of abaloparatide for fracture healing , PI . Sponsor: VA, Sponsor Award ID: 1I01 BX005854
  • July 15, 2021 - June 3, 2026 - Maladaptive Plasticity in Spinal Cord Injury: Cellular Mechanisms , PI of subcontract . Sponsor: NIH, Sponsor Award ID: R01NS122888
  • June 1, 2022 - May 31, 2026 - Biomechanical computed tomography facilitates the diagnosis of osteoporosis and fracture prediction in patients with high risk prostate cancer , PI . Sponsor: DOD, Sponsor Award ID: PC210172
  • January 1, 2018 - December 31, 2021 - Vitamin D and Calcium signaling in epidermal stem cell maintenance, activation, and function , Principal Investigator . Sponsor: NIH, Sponsor Award ID: I01BX003814
  • April 1, 2008 - January 31, 2021 - Role of IGF-I/integrin signaling in the periosteal response to load , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AR055924
  • July 1, 2003 - May 31, 2016 - Vitamin D Receptor Coactivators in Keratinocytes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AR050023
  • February 15, 2001 - August 31, 2015 - IGF-1 Mediates the Anabolic Effects of PTH on Bone , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK054793
  • March 1, 1982 - May 31, 2015 - Bio-Organic Biomedical Mass Spectrometry Resource , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR001614
  • July 15, 1988 - July 31, 2010 - Relationship of Keratinocyte Function to Differentiation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P01AR039448
  • May 1, 1987 - March 31, 2005 - VITAMIN D AND THE DIFFERENTIATION OF KERATINOCYTES , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AR038386
  • April 1, 1981 - June 30, 2004 - REGULATION OF INTESTINAL CALCIUM TRANSPORT BY VITAMIN D , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK028116
  • September 30, 1995 - March 31, 1999 - ESTROGEN/CALCITRIOL IN THE ETIOLOGY OF BREAST CANCER , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R03CA070572
  • April 1, 1981 - March 31, 1987 - VITAMIN D STIMULATED INTESTINAL CALCIUM TRANSPORT , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AM028116

Education

Harvard University, AB, 1961-1965
University of Pennsylvania, MD, 1965-1969
Peter Bent Brigham Hospital, Boston, Intern, Resident, 1970-1971
University of Pennsylvania, PhD, 1971-1974, Biochemistry

Honors & Awards

  • 1971, 1974
    National Institutes of Health Special Postdoctoral Fellowship
  • 1982
    Fellowship, American College of Physicians
  • 1985
    American Society of Clinical Investigation
  • 1988
    Western Association of Physicians
  • 1995
    Association of American Physicians
  • 1997
    Fellowship, Molecular Medicine
  • 2007
    Boy Frame Award for Clinical Excellence in the Field of Bone and Mineral Research, ASBMR
  • 2009
    Career Award in Vitamin D Research, International Vitamin D Workshop
  • 2016
    Louis V Avioli Founders Award, ASBMR
  • 2019
    Fellow, ASBMR

Selected Publications

  1. Giustina A, Bilezikian JP, Adler RA, Banfi G, Bikle DD, Binkley NC, Bollerslev J, Bouillon R, Brandi ML, Casanueva FF, di Filippo L, Donini LM, Ebeling PR, Fuleihan GE, Fassio A, Frara S, Jones G, Marcocci C, Martineau AR, Minisola S, Napoli N, Procopio M, Rizzoli R, Schafer AL, Sempos CT, Ulivieri FM, Virtanen JK. Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows. Endocr Rev. 2024 Sep 12; 45(5):625-654.  View on PubMed
  2. Demay MB, Pittas AG, Bikle DD, Diab DL, Kiely ME, Lazaretti-Castro M, Lips P, Mitchell DM, Murad MH, Powers S, Rao SD, Scragg R, Tayek JA, Valent AM, Walsh JME, McCartney CR. Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2024 Jul 12; 109(8):1907-1947.  View on PubMed
  3. Bikle DD. Vitamin D and Long COVID: Is There a Role in Prevention or Treatment? J Clin Endocrinol Metab. 2023 Dec 21; 109(1):e430-e431.  View on PubMed
  4. Lin JK, Hearn CM, Getzen E, Long Q, Lee DC, Keaveny TM, Jayadevappa R, Robinson KW, Wong YN, Maxwell KN, Narayan V, Haas NB, Takvorian SU, Bikle DD, Chiang JM, Khan AN, Rajapakse CS, Morgans AK, Parikh RB. Validation of Biomechanical Computed Tomography for Fracture Risk Classification in Metastatic Hormone-sensitive Prostate Cancer. Eur Urol Oncol. 2024 Aug; 7(4):794-803.  View on PubMed
  5. Thaler R, Yoshizaki K, Nguyen T, Fukumoto S, Den Besten P, Bikle DD, Oda Y. Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics. Commun Biol. 2023 07 21; 6(1):766.  View on PubMed
  6. Oda Y, Wong CT, Oh DH, Meyer MB, Pike JW, Bikle DD. Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate. J Steroid Biochem Mol Biol. 2023 09; 232:106352.  View on PubMed
  7. Giustina A, di Filippo L, Allora A, Bikle DD, Cavestro GM, Feldman D, Latella G, Minisola S, Napoli N, Trasciatti S, Uygur M, Bilezikian JP. Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship? Rev Endocr Metab Disord. 2023 04; 24(2):121-138.  View on PubMed
  8. Meyer MB, Bernal-Mizrachi C, Bikle DD, Biyani M, Campbell MJ, Chaudhari SN, Christakos S, Ingles SA, Knuth MM, Lee SM, Lisse TS, Liu ES, Piec I, Plum LA, Rao SD, Reynolds CJ, Thacher TD, White JH, Cantorna MT. Highlights from the 24th workshop on vitamin D in Austin, September 2022. J Steroid Biochem Mol Biol. 2023 04; 228:106247.  View on PubMed
  9. Teng PF, Chiang JM, Schafer AL, Sukerkar PA, Keaveny TM, Bikle D. Prevalence of osteoporosis in older male veterans receiving hip-containing computed tomography scans: opportunistic use of biomechanical computed tomography analysis (BCT). Osteoporos Int. 2023 Mar; 34(3):551-561.  View on PubMed
  10. Mauro T, Bikle D. Skin and bone crosstalk during aging. Nat Aging. 2022 10; 2(10):874-875.  View on PubMed
  11. Bikle DD. Role of vitamin D and calcium signaling in epidermal wound healing. J Endocrinol Invest. 2023 Feb; 46(2):205-212.  View on PubMed
  12. Seal KH, Bertenthal D, Bikle DD. Response to Letters to the Editor RE: Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. J Gen Intern Med. 2022 10; 37(13):3494.  View on PubMed
  13. Bikle DD. Vitamin D Regulation of Immune Function. Curr Osteoporos Rep. 2022 06; 20(3):186-193.  View on PubMed
  14. Bikle DD. Vitamin D regulation of immune function during covid-19. Rev Endocr Metab Disord. 2022 04; 23(2):279-285.  View on PubMed
  15. Seal KH, Bertenthal D, Carey E, Grunfeld C, Bikle DD, Lu CM. Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. J Gen Intern Med. 2022 03; 37(4):853-861.  View on PubMed
  16. Bikle DD. Ligand-Independent Actions of the Vitamin D Receptor: More Questions Than Answers. JBMR Plus. 2021 Dec; 5(12):e10578.  View on PubMed
  17. Gonciulea AR, Wang Y, Bikle DD, Sellmeyer DE. Hypercalcemia in non-Hodgkin's lymphoma due to cosecretion of PTHrP and 1,25-dihydroxyvitamin D. Osteoporos Int. 2021 Dec; 32(12):2587-2592.  View on PubMed
  18. Bikle DD. Vitamin D regulation of and by long non coding RNAs. Mol Cell Endocrinol. 2021 07 15; 532:111317.  View on PubMed
  19. Celli A, Tu CL, Lee E, Bikle DD, Mauro TM. Decreased Calcium-Sensing Receptor Expression Controls Calcium Signaling and Cell-To-Cell Adhesion Defects in Aged Skin. J Invest Dermatol. 2021 11; 141(11):2577-2586.  View on PubMed
  20. Bouillon R, Haussler M, Bikle D, Christakos S, Welsh J. Introduction: Special Issue on Vitamin D Dedicated to the Memory of Anthony W Norman. JBMR Plus. 2021 Jan; 5(1):e10445.  View on PubMed

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